Yeah.
Darkesst Dungeon, baldur's gate 3, Sims 4, Skyrim, Fallout, Risk of Rain 2, Helldivers 2, Deep rock Galactic, Crusader Kings 3, Stellaris and the list goes on
I have a poblem. If I start modding the game it feels I'm spending more time modding than playing, which then transitions to tweaking mods and then forking them... So, as a solution, I'm not modding my games, with one exception regarding very small and self-contained UI mods.
Really depends on the game for me, if it's an open world or nonlinear game, sure why not? But if it's a heavily story driven experience, lewd mods would just ruin it.
It also depends on the convenience; I tried getting into modding Skyrim but every mod has 50 different versions and half of them will crash the game if paired with X mod without Y loader and Z game version.